RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development

By John J. Rossi

RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA (small interfering RNA), a pharmaceutically potent form, and its use and delivery in therapeutics along with manufacturing and delivery aspects.

• Language: English
• Publisher: Wiley
• Release date: Nov 17, 2010
• ISBN: 9780470923726

John J. Rossi

Dr. John J. Rossi is Lidow Family Research Endowed Chair and Professor in the Dept. of Molecular and Cellular Biology, Beckman Research Institute of the City of Hope. He currently serves as the Morgan and Helen Chu Dean’s Chair, and Dean of Irell & Manella Graduate School of Biological Sciences. He served as an Associate Director of Laboratory Research – City of Hope Comprehensive Cancer Center for City of Hope. He joined City of Hope, Inc. (COH) in 1980 as an Assistant Research Scientist in the Department of Molecular Genetics. He was Chairman of the Division of Biology in 1992. In 1993, COH bestowed its highest honor upon him by naming him to its Gallery of Medical and Scientific Achievement for his pioneering work at the molecular level in the battle against AIDS and other major diseases.