This audio program discusses combining medications for depression; switching from polypharmacy to monotherapy for schizophrenia; combining gabapentin with naltrexone for alcohol dependence; treatments for refractory depression in older patients; the balance between habit formation and goal-directed behavior displayed by obsessive-compulsive disorder patients as they perform an instrumental learning exercise; and the ability of soldiers’ visual fixation on emotional stimuli to predict PTSD and depressive symptoms after deployment. Articles can be viewed online at www.ajp.psychiatryonline.org.