This audio program discusses factors related to the emergence of mania during antidepressant treatment for bipolar depression; manic symptoms observed during bipolar depression among STEP-BD participants; the attitude of older adults toward enrollment of noncompetent subjects in Alzheimer’s disease research; the association between cerebral deficits and clinical symptoms in antipsychotic-naive, first-episode schizophrenia patients; whether altered amygdala activity in schizophrenia is related to clinical state or to genetic risk; brain structure in schizophrenia patients with relatively intact cognitive functioning; and an odor-detection sensitivity deficit in patients with schizophrenia and its implications for cyclic AMP signaling. Articles can be viewed online at www.ajp.psychiatryonline.org.