1) Causes, management and predictors of outcome in acute encephalitis and 2) Topic of the month: Myelopathy due to systemic disease. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Mike Brogan interviews Dr. Alejandro Rabinstein about his paper on the causes, management and predictors of outcome in acute encephalitis. Dr. Sarah Wesley is reading our e-Pearl of the week about Charcot-Marie-Tooth. In the next part of the podcast Dr. Ted Burns interviews Dr. Steven L. Lewis about the topic of myelopathy due to systemic disease: chemo, mets, AMN, organ/failure/dysfxn and extramed hemato. The participants had nothing to disclose except Drs. Canning, Wesley, Burns and Lewis.Dr. Rabinstein serves as an Associate Editor of Neurocritical Care, serves as an editorial board member of Neurology®, served on the safety monitoring board for the PREVAIL trial; receives royalties from the publication of the books Practical Neuroimaging in Stroke and What To Do? Neurocritical Care and receives research support from DJO Global.Dr. Wesley serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with CSL Behring and Alexion Pharmaceuticals, Inc.Dr. Lewis serves as CME Section Co-Editor for Neurology® and as Editor in Chief for Continuum: Lifelong Learning in Neurology®; received royalties for book authorship and editorship from the publishers Wolters Kluwer and Wiley- Blackwell.