Listen to George L. Bakris, MD, FAHA, FASN, Cecilia C. Low Wang, MD, FACP and Neda Rasouli, MD educate clinicians on the updates made in the 2021 ADA Standards of Care related to metformin use and considerations for when the guideline recommends considering use of SGLT-2 Inhibitors and GLP-1 receptor agonists independent of A1C or metformin use.