Today’s episode is part business breakdown and part biology breakdown as we explore Finch Therapeutics and their novel work on the microbiome, which plays a crucial role in regulating our immune system.   To help break down these topics, I’m joined by Mark Smith, co-founder and CEO of Finch Therapeutics. Mark is a leader in the microbiome field and the perfect person to cross the bridge between business and science.   As Mark outlines, we’ve made a lot of progress in living longer, but we are yet to make significant steps to living better. In our discussion, we explore what the microbiome is, why it’s so important, and the role that Finch plays in helping patients transform their lives. We then turn to the business side of developing therapeutics drugs and what Mark has learned there. Please enjoy this breakdown of Finch Therapeutics.   For the full show notes, transcript, and links to the best content to learn more, check out the episode page here.   -----   This episode is brought to you by Brex. Brex began as the first corporate card for startups and now offers a full financial stack built for scale. Get 10-20x higher credit limits, uncapped rewards, easy deposits and payments, and expense management all in one. Grow your business faster with Brex.   -----   Scribe is the trusted transcription provider for the business and investing community. Scribe is designed to accurately transcribe messy, real-world audio and is unique in that it’s optimized for the complexities of enterprise audio, such as company and product names, currencies, accents and numbers. Visit kensho.com/breakdowns to learn more and unlock your free trial.   -----   Business Breakdowns is a property of Colossus, LLC. For more episodes of Business Breakdowns, visit joincolossus.com/episodes.   Stay up to date on all our podcasts by signing up to Colossus Weekly, our quick dive every Sunday highlighting the top business and investing concepts from our podcasts and the best of what we read that week. Sign up here.   Follow us on Twitter: @JoinColossus | @patrick_oshag | @jspujji | @zbfuss Show Notes [00:02:55] - [First question] - What is the microbiome? [00:04:56] - Where the microbiome is inside the body [00:06:42] - Overview of what bacteria is in general terms and what they do for us [00:10:44] - What would happen to a human that didn’t have any bacteria [00:13:29] - Inflammatory auto-immune diseases and widespread antibiotics [00:14:32] - How seasonal allergies and gut bacteria are related [00:16:32] - Key contributors that have led to our current understanding of the microbiome [00:18:48] - Whether an absence or dominance of bacteria is more concerning [00:20:47] - The state of stool sample diagnostics today [00:22:52] - Tools available today for widespread microbial treatment and repair [00:24:48] - The science behind probiotics and whether or not they’re worth it [00:27:00] - Fecal transplants and supporting empirical evidence of their efficacy [00:31:39] - Addressable conditions that Finch Therapeutics seeks to solve [00:35:27] - What the end game looks like and the timeline to achieve it [00:40:05] - Is there a future where we use these therapeutics preventatively? [00:41:22] - Key risks that could threaten the growth of Finch in the coming decade [00:43:10] - What it’s been like running a company that is so different than its competitors [00:45:51] - Whether or not the regulatory and iterative pace of therapeutics will increase [00:48:19] - How much his lifestyle has changed given what he knows now in this field [00:50:50] - Other innovations taking place in the microbiome and related therapeutics [00:52:28] - What most has his attention outside of his field in health science today [00:53:24] - Learn more about the microbiome; I Contain Multitudes (book) [00:53:42] - The kindest thing anyone has ever done for him