Although genome sequencing has helped scientists reveal proteins wreaking havoc in our bodies, that doesn’t guarantee scientists can invent the drugs to take them down. Depending on who you talk to, up to 85% of the human proteome is currently “undruggable,” meaning these proteins lack easy-to-find pockets where therapeutics, such as small molecules, can bind. But a wave of biotech companies, each one armed with new technology, has arrived to tackle the problem. Industry and academic scientists explain why they think the business and scientific environment is ripe for finally overcoming the most elusive drug targets. For a full transcript and more links, visit https://cen.acs.org/pharmaceuticals/drug-discovery/quest-drug-undruggable/96/i26 Subscribe to Stereo Chemistry now on iTunes, Google Play, or TuneIn. “Soundboy” by 4bstr4ck3r is licensed under CC BY-4.0. http://freemusicarchive.org/music/4bstr4ck3r/4bstr4ck3r/4bstr4ck3r_-_4bstr4ck3r_-_01_Soundboy_CC-BY-NC “The Ascent” by A. A. Aalto is licensed under CC BY-NC 3.0. http://freemusicarchive.org/music/A_A_Aalto/Bright_Corners/The_Ascent “The Confrontation” by Podington Bear is licensed under CC BY-NC 3.0. http://freemusicarchive.org/music/Podington_Bear/Passages/The_Confrontation