Typhoid fever is a disease that, in the United States, is synonymous with Mary Mallon—a woman better known as Typhoid Mary, who infected New Yorkers with typhoid in the early 1900s. But typhoid is not just a thing of the past. Across the globe every single year, it kills over 100,000 people. And over the last few years, even in countries like the US where typhoid hasn’t been a concern for generations, the number of reported cases is climbing. So why is typhoid making a comeback? And what are scientists doing to stop it?  For a transcript of the episode, head to: http://www.acs.org/tinymatters