On this episode, I discuss losartan pharmacology, adverse effects, drug interactions, and appropriate monitoring.



Losartan is an ARB and can increase potassium levels. Keep an eye out for medications like spironolactone and trimethoprim which can increase this risk further.



Losartan has been shown to lower uric acid levels which could potentially be helpful in patients with gout.



Monitoring renal function is very important with losartan. The risk of ARF goes significantly higher when used with NSAIDs or diuretics.