A staggering quarter of a billion people worldwide have diabetes, with this figure set to rise to 380 million by 2025. In this week's podcast, Jane Godsland discusses many of the topics in the May 24-30 diabetes issue of The Lancet: research showing that intensive insulin therapy given early after diagnosis of type 2 diabetes can reverse disease progression; public-health interventions in a Chinese population study highlighting how appropriate diet and exercise can delay the onset of diabetes; and discussion of other research, reviews, and diabetes content in this week's Perspectives section of the journal.