CDC Director Rochelle P. Walensky, MD, MPH, returns to JAMA's Q&A series to discuss the agency's response to emerging SARS-CoV-2 variants, implications for the planned vaccine mobilization strategy, the upcoming Johnson & Johnson vaccine FDA advisory hearings, strategies for reopening K-12 schools, and other agency activities and priorities related to COVID-19 control. Recorded February 17, 2021. Related Article(s): Coronavirus Update With CDC Director Rochelle Walensky - February 17, 2021 SARS-CoV-2 Variants of Concern in the United States—Challenges and Opportunities SARS-CoV-2 Viral Variants—Tackling a Moving Target