On this week’s episode of Fast Facts - Perio Edition, Katrina Sanders, we are continuing the conversation around periodontitis as a manifestation of systemic disease discussing patients that present with Chediak-Higashi Syndrome.   Quotes:    “So these individuals who present with Chediak-Higashi will oftentimes experience the ramifications associated with having a declined immune system, which for these individuals is often times experienced in advanced signs, stages, or symptoms of periodontitis.”   “I want you to think about all of this like a super highway system where things are constantly moving around. The challenge is in an individual who has this relatively obscure congenital or inherited defect, these individuals have some type of an issue in which their abnormal gene affects those traffic patterns or the ways in which proteins will move throughout the body and into cells.” Resources:   DentistRX: https://www.dentistrx.com  More Fast Facts: https://www.ataleoftwohygienists.com/fast-facts/    Katrina Sanders Website: https://www.katrinasanders.com  Katrina Sanders Instagram: https://www.instagram.com/thedentalwinegenist/    Sources: Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., ... & Tonetti, M. S. (2018). Jepsen S, Caton JG, Albandar JM, Bissada NF, Bouchard P, Cortellini P, Demirel K, de Sanctis M, Ercoli C, Fan J, Geurs NC, Hughes FJ, Jin L, Kantarci A, Lalla E, Madianos PN, Matthews D, McGuire MK, Mills MP, Preshaw PM, Reynolds MA, Sculean A, Susin C, West NX, Yamazaki K. Periodontal manifestations of systemic diseases and developmental and acquired conditions: Consensus report of workgroup 3 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. J Periodontol. 2018 Jun;89 Suppl 1:S237-S248. doi: 10.1002/JPER.17-0733. PMID: 29926943.