This podcast will review an approach to a pediatric and ophthalmic emergency: retinoblastoma. We will review the pathophysiology, pertinent history and physical examination findings, appropriate investigations, and management of retinoblastoma. This podcast has been created by Ojas Srivastava, 3rd year medical student, Kim Papp, 2nd year medical student, Dr. Meghan Smith, Chief Ophthalmology Resident, and Dr. Carlos Solarte, Pediatric Ophthalmologist, all at the University of Alberta.