In this episode, Jason Gallagher, PharmD, and Emily Heil, PharmD, MS, BCIDP discuss landmark clinical trials of COVID-19 antivirals for nonhospitalized patients and COVID-19 rebound phenomenon, including:  EPIC-HR study of nirmatrelvir plus ritonavirPINETREE study of remdesivirMOVe-OUT and Panoramic studies of molnupiravirCOVID-19 rebound in treated and untreated patientsPresenters:Jason Gallagher, PharmDClinical ProfessorSchool of PharmacyTemple UniversityClinical Pharmacy SpecialistInfectious DiseasesTemple University HospitalPhiladelphia, PennsylvaniaEmily Heil, PharmD, MS, BCIDP, AAHIVPAssociate ProfessorDepartment of Pharmacy Practice and ScienceUniversity of Maryland School of PharmacyInfectious Diseases Clinical Pharmacy SpecialistUniversity of Maryland Medical CenterBaltimore, Maryland