Lung transplantation has become an option of last resort for a small subset of patients with COVID-19-related acute respiratory distress syndrome (ARDS) or pulmonary fibrosis. Ankit Bharat, MD, chief of Thoracic Surgery and director of Lung Transplant and ECMO at Northwestern Memorial Hospital in Chicago, discusses his experience performing lung transplants for patients with respiratory failure due to COVID-19, including the first successful double lung transplant in the US for a patient with COVID-19-related ARDS. Related Content: Lung Transplants for COVID-19—The Option of Last Resort