Proceedings from a daylong symposium hosted in partnership with North Carolina Oncology Association and South Carolina Oncology Society, featuring key clinical presentations and papers in acute myeloid leukemia and myelodysplastic syndromes, breast cancer, chronic lymphocytic leukemia and lymphomas, gastrointestinal cancers, genitourinary cancers, lung cancer and multiple myeloma. Featuring perspectives from Drs Courtney D DiNardo, Robert Dreicer, Justin F Gainor, Sara Hurvitz, Ian E Krop, John M Pagel, Alexander Perl, Daniel P Petrylak, Philip A Philip, Paul G Richardson, Mitchell R Smith, Prof Eric Van Cutsem and Drs Peter Voorhees and Heather Wakelee, moderated by Dr Neil Love.