Frailty and a decline in overall physical strength are irksome signs of aging.  Regular exercise is essential to maintain optimum muscle mass and movement, but are there other interventions that could curb age-related muscle weakening?  A Swiss biotech startupis developing a supplement that could slow down the process, by replacing damaged mitochondria, the parts of cells that generate energy. It turns out that a key component could be a chemical produced by the gut microbiome, when we eat pomegranates and strawberries.  In this LLAMA podcast with Peter Bowes, Dr. Anurag Singh, Chief Medical Officer with Amazentis, explains the background to this developing science and its potential to help older people maintain an independent lifestyle for longer.Check out our website at LLAMApodcast.comIn this interview we cover:  Research at Amazentis and company missionDr. Singh’s transition from medical practice to medical researchThe role of mitochondria - the cellular powerhouses - and link to muscle dysfunction or declineAnalysing the mitochondrial health of frail vs older, active adults.The connection between pomegranates, strawberries and nuts - and mitochondrial health. The role of urolithin A and why it could be a valuable dietary supplement.Why microbiome health is linked to muscle strength.Why optimal diet is not equal to optimal health.The role of mitophagy. Animal studies suggesting urolithin A supplementation promotes enhanced endurance and better mitochondrial function.What the first clinical studies with older, minimally active human subjects show. The current fascination with longevity research and desire to function better for longer. FlexBeam red light therapyRecharge Health is offering LLAMA listeners an $80.00 discount on the purchase of FlexBeam, the wearable red light therapy device which targets key parts of the body to improve sleep, treat injuries and sooth aches and pains associated with aging.  Use code LLAMA at checkout- DoNotAgeDoNotAge.org is offering listeners to LLAMA a 10% discount on its range of products – NAD boosters, Sirtuin activators, senolytics and more.  Any health queries can be answered by emailing the team at hello@donotage.orgUse the code LLAMA at checkout. - Time-line Mitopure (a highly pure form of Urolithin A) boosts the health of our mitochondria – the battery packs of our cells – and improves muscle strength. Time-line is offering LLAMA listeners a 10% discount on its range of products – Mitopure powders, softgels & skin creams.  Use the code LLAMA at checkout-Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice. If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.