#015-What is the best way to detect ketosis?Ketones and ketosis are everywhere in the news. What are ketone bodies?Why are they good for us? How do we measure them?  Our guest today is Jim Howard, the CEO of biomarker-based startup Readout Health. Their product  Biosense is the first clinical-grade, handheld device that measures nutritional ketosis for chronic disease and longevity/wellness focused consumers. He is a digital health executive with an MBA from University of Missouri-Saint Louis.Take away points:Three Ketone bodies are produced as a by‐product of fat metabolism. When the liver metabolizes free fatty acids,  they are transformed into acetyl‐CoA, a molecule used in the production of energy. Depending on the glucose level, acetyl‐CoA can be diverted to  produce acetoacetate, the first of three ketone bodies.  Acetoacetate can further produce β‐hydroxybutyrate and acetone, by enzymatic degradation or spontaneous decarboxylation respectively.All three ketone bodies circulate in the bloodstream. Acetone, because of its small size, diffuses into the lung and appears in the exhaled breath. The devices we will be discussing detect levels of acetone from this process.Deep lung measurement.Biosense Breath Ketone Monitor -Use the code Lufkin20 for a $20 discount at https://mybiosense.com/*** CONNECT WITH ROBERT LUFKIN MD ON SOCIAL MEDIA ***Web: https://robertlufkinmd.com/ Twitter:https://twitter.com/robertlufkinmd*** GOT A SUGGESTION FOR A SHOW? ***Contact us at: https://robertlufkinmd.com/contact*** SPONSORSHIPS & BRANDS *** We do work with sponsors and brands. If you are interested in working with us and you have a product or service that is of value to the health industry please contact us at: https://robertlufkinmd.com/contactNOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here. Robert Lufkin MD may at any time and at its sole discretion change or replace the information available on this channel. To the extent per*** CONNECT WITH ROB ON SOCIAL MEDIA ( ~250k)*** Web: https://robertlufkinmd.com/X(Twitter): https://twitter.com/robertlufkinmdYoutube: https://www.youtube.com/RobertLufkinMDInstagram: https://www.instagram.com/robertlufkinmd/LinkedIn: https://www.linkedin.com/in/robertlufkinmd/Threads: https://www.threads.net/@robertlufkinmd *** SPONSORSHIPS & BRANDS ***We do work with sponsors and brands. If you are interested in working with us for your health industry product or service, please contact us at: https://www.robertlufkinmd.com/contact/ NOTE: This is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have. Never disregard professional medical advice or delay in seeking it because of something you have seen here.