Spaceflight-associated neuro-ocular syndrome (SANS) is a constellation of findings that often present in astronauts who have undergone long-duration space flight in microgravity environments. Astronauts with SANS may have disc edema, choroidal folds, cotton wool spots, nerve fiber layer thickening on OCT, globe flattening, and hyperopic shift. In today's episode, neuro-ophthalmologist and NASA consultant Dr. Andy Lee shares what we know about SANS and its implications on our terrestrial knowledge, technology, and the future. For all episodes or to claim CME credit for selected episodes, visit www.aao.org/podcasts.