Hypertension, commonly known as high blood pressure, is a silent yet prevalent health issue that affects millions of people worldwide. Often going unnoticed until significant damage has been done, hypertension can lead to severe cardiovascular complications if not properly managed. Mechanistically, the causes of hypertension are complex, involving both genetic and lifestyle factors. The management of hypertension presents multifaceted challenges, encompassing both pharmaceutical treatments and lifestyle modifications. From a prevention and management standpoint, understanding the interplay between genetics and lifestyle is crucial. This raises several important questions… To what extent do genetic factors contribute to hypertension risk compared to lifestyle choices, and how does this interaction influence disease progression? What role does lifestyle play in managing hypertension, and is there evidence supporting the influence of specific dietary patterns and nutrients, particularly sodium and potassium, on blood pressure control? How do exercise and physical activity impact blood pressure, and what types of exercise are most beneficial for individuals with or at risk of hypertension? What are the main categories of antihypertensive medications, and how do these drugs work to lower blood pressure? What are the potential side effects, and how should clinicians decide on the best treatment approach for individual patients? In this episode, we are joined by Dr. Mohammed Alo, a board-certified cardiologist and internal medicine specialist, who will help us understand the intricacies of hypertension and how it can be effectively controlled. Links: Go to episode page dralo.net/ Receive our free weekly email: the Sigma Synopsis Subscribe to Sigma Nutrition Premium Timestamps: 03:28 Dr. Alo’s Background and Expertise 08:40 Understanding Blood Pressure and Its Implications 10:26 Causes and Diagnosis of High Blood Pressure 12:42 Lifestyle Modifications and Treatment Options 30:26 Medications for Blood Pressure Management 38:34 Combination Therapy and Patient Variability 43:11 Debunking Myths About Sodium and Blood Pressure 57:29 Exercise and Lifestyle Interventions