To engineer yeast to do more, and understand genomes in general, Jef Boeke, Weimin Zhang (NYU Langone Health) and Leslie Mitchell (Neochromosome) have worked to replace yeast’s native chromosomes with synthetic versions. This project has turned out to be an international collaboration, with some artistic endeavors along the way. Eventually, the goal is to create an entirely human-generated yeast genome.Links from this episode:Submit your own proposal to work with the JGIJoin us at the 2024 JGI User MeetingEpisode TranscriptPaper: Manipulating the 3D organization of the largest synthetic yeast chromosomeNYU Release: Researchers Assemble Nine Synthetic Yeast ChromosomesOur contact info:X: @JGIEmail: jgi-comms at lbl dot gov